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DeCS
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Descriptor English:
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Mice, Inbred MRL lpr
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Descriptor Spanish:
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Ratones Consanguíneos MRL lpr
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Descriptor Portuguese:
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Camundongos Endogâmicos MRL lpr
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Synonyms English:
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Mice, MRL lpr
Mouse, Inbred MRL lpr
Mouse, MRL lpr
MRL lpr Mice
MRL lpr Mouse
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Tree Number:
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B01.050.050.199.520.520.555
B01.050.150.900.649.313.992.635.505.500.400.555
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Definition English:
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A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents. |
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Indexing Annotation English:
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a strain predisposed to develop of systemic lupus erythematosus; MRL stands for "Murphy-Roths Lymphoma", lpr stands for "LymphoPRoliferative"; NIM when exper animal: no qualif; when IM, qualif permitted; do not forget also to check MICE; in titles & translations use lpr (the letter l), not 1pr (the figure one)
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History Note English:
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97
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Allowable Qualifiers English:
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Record Number:
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32887
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Unique Identifier:
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D019463
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Occurrence in VHL:
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Similar:
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DeCS CID-10 LILACS
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